2-Bromo-1,3-thiazole-4-carboxamide → 2-(4-{[(4-Bromo-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-1,3-thiazole-4-carboxamide

HRID 2233970Notes

Reaction equation

HRID 2233970 reaction equation
Cl.[Br:2][C:3]1[CH:4]=[C:5]([C:9]([NH:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:10])[NH:6][C:7]=1[CH3:8].Br[C:19]1[S:20][CH:21]=[C:22]([C:24]([NH2:26])=[O:25])[N:23]=1>>[Br:2][C:3]1[CH:4]=[C:5]([C:9]([NH:11][CH:12]2[CH2:13][CH2:14][N:15]([C:19]3[S:20][CH:21]=[C:22]([C:24]([NH2:26])=[O:25])[N:23]=3)[CH2:16][CH2:17]2)=[O:10])[NH:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 457896322-Bromo-1,3-thiazole-4-carboxamideHCID 68579819HCID 68579819, compound2×

Product 1

HCID 685827172-(4-{[(4-Bromo-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-1,3-thiazole-4-carboxamide

Procedure

Title compound was synthesized by an analogous method to Example 123 by coupling 4-bromo-5-methyl-N-piperidin-4-yl-1H-pyrrole-2-carboxamide hydrochloride (Intermediate 57) with 2-bromo-1,3-thiazole-4-carboxamide (J. Am. Chem. Soc. 1952, 74, 5799).

Sources & evidence

ORD record
ord-b3e6c084a2144d50b15e9a562c338def
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

Loading…