HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1,3-thiazole-4-carboxamide → 2-(4-{[(4-Bromo-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-1,3-thiazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1,3-thiazole-4-carboxamide | HCID 45789632 | — |
| Reactant | HCID 68579819 | HCID 68579819 | — |
| Product | 2-(4-{[(4-Bromo-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-1,3-thiazole-4-carboxamide | HCID 68582717 | — |
Reaction Steps
Title compound was synthesized by an analogous method to Example 123 by coupling 4-bromo-5-methyl-N-piperidin-4-yl-1H-pyrrole-2-carboxamide hydrochloride (Intermediate 57) with 2-bromo-1,3-thiazole-4-carboxamide (J. Am. Chem. Soc. 1952, 74, 5799).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709503B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-b3e6c084a2144d50b15e9a562c338def |
| Source note | uspto-grants-2010_05 |