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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2233976Generated: October 30, 2026

O-Methylhydroxylamine hydrochloride → 2-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-6-[2-(dimethylamino)ethoxy]-N-methoxyisonicotinamide

https://huagongshe.com/reaction/2233976

Reaction equation

Participants

RoleNameHCIDCharge
ReactantO-Methylhydroxylamine hydrochlorideHCID 521874—
Reactant2-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-6-[2-(dimethylamino)ethoxy]isonicotinic acidHCID 68579907—
Product2-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-6-[2-(dimethylamino)ethoxy]-N-methoxyisonicotinamideHCID 86608322—

Reaction Steps

The title compound was prepared as described for Example 8 from 2-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-6-[2-(dimethylamino)ethoxy]isonicotinic acid (Example 139) acid and O-methylhydroxylamine hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07709503B2
Source datasetuspto-grants-2010_05
ORD IDord-f05b7d51ff864cf6b104edc646b4ec0e
Source noteuspto-grants-2010_05