O-Methylhydroxylamine hydrochloride → 2-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-6-[2-(dimethylamino)ethoxy]-N-methoxyisonicotinamide
Reaction equation
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:24]=[C:25]([O:27][CH2:28][CH2:29][N:30]([CH3:32])[CH3:31])[N:26]=2)[C:21](O)=[O:22])[CH2:14][CH2:13]1)=[O:10].Cl.[CH3:34][O:35][NH2:36]>>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:24]=[C:25]([O:27][CH2:28][CH2:29][N:30]([CH3:32])[CH3:31])[N:26]=2)[C:21]([NH:36][O:35][CH3:34])=[O:22])[CH2:14][CH2:13]1)=[O:10]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared as described for Example 8 from 2-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-6-[2-(dimethylamino)ethoxy]isonicotinic acid (Example 139) acid and O-methylhydroxylamine hydrochloride.
Sources & evidence
- ORD record
- ord-f05b7d51ff864cf6b104edc646b4ec0e
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07709503B2
Reaction notes
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