O-Methylhydroxylamine hydrochloride → HCID 86608332, compound

HRID 2233988Notes

Reaction equation

HRID 2233988 reaction equation
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[N:23]=[C:22]([N:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)[N:21]=[C:20]([C:30](O)=[O:31])[CH:19]=2)[CH2:14][CH2:13]1)=[O:10].Cl.[O:34]([NH2:36])[CH3:35]>>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:13][CH2:14][N:15]([C:18]2[N:23]=[C:22]([N:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)[N:21]=[C:20]([C:30]([NH:36][O:34][CH3:35])=[O:31])[CH:19]=2)[CH2:16][CH2:17]1)=[O:10]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 68579634HCID 68579634, compound

Product 1

HCID 86608332HCID 86608332, compound

Procedure

The title compound was synthesized by an analogous method to Example 8 starting from 6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-piperazin-1-ylpyrimidine-4-carboxylic acid (Example 194) and methoxylamine hydrochloride.

Sources & evidence

ORD record
ord-64a4d34e558742e98211906e6fd82144
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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