Lithium Hydroxide → HCID 68580126, compound

HRID 2233989Notes

Reaction equation

[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[N:23]=[C:22]([N:24]3[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]3)[N:21]=[C:20]([C:31]([O:33]C)=[O:32])[CH:19]=2)[CH2:14][CH2:13]1)=[O:10].[OH-].[Li+]>>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:13][CH2:14][N:15]([C:18]2[N:23]=[C:22]([N:24]3[CH2:25][CH2:26][N:27]([CH3:30])[CH2:28][CH2:29]3)[N:21]=[C:20]([C:31]([OH:33])=[O:32])[CH:19]=2)[CH2:16][CH2:17]1)=[O:10]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 68580114HCID 68580114, compound

Product 1

HCID 68580126HCID 68580126, compound

Procedure

The title compound was synthesized by an analogous method to Example 310 starting from methyl 6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-(4-methylpiperazin-1-yl)pyrimidine-4-carboxylate (Example 318) and 2 N lithium hydroxide.

Sources & evidence

ORD record: ord-39602ab0839345e7af244af9010f24f0
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07709503B2

Reaction notes

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