O-Methylhydroxylamine hydrochloride → HCID 86608333, compound

HRID 2233990Notes

Reaction equation

HRID 2233990 reaction equation
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[N:23]=[C:22]([N:24]3[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]3)[N:21]=[C:20]([C:31]([OH:33])=O)[CH:19]=2)[CH2:14][CH2:13]1)=[O:10].Cl.[O:35]([NH2:37])[CH3:36]>>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:13][CH2:14][N:15]([C:18]2[N:23]=[C:22]([N:24]3[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]3)[N:21]=[C:20]([C:31]([NH:37][O:35][CH3:36])=[O:33])[CH:19]=2)[CH2:16][CH2:17]1)=[O:10]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 68580126HCID 68580126, compound

Product 1

HCID 86608333HCID 86608333, compound

Procedure

The title compound was synthesized by an analogous method to Example 8 starting from 6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-(4-methylpiperazin-1-yl)pyrimidine-4-carboxylic acid (Example 196) and methoxylamine hydrochloride.

Sources & evidence

ORD record
ord-75d89546a6db41fc9112e2ca0e87d717
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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