HCID 68579996, compound → Methyl 2-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-6-(ethylthio)pyrimidine-4-carboxylate

HRID 2233993Notes

Reaction equation

HRID 2233993 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[C:4]([S:12][CH2:13][CH3:14])[N:3]=1.Cl.[Cl:16][C:17]1[C:21]([Cl:22])=[C:20]([CH3:23])[NH:19][C:18]=1[C:24]([NH:26][CH:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)=[O:25]>>[Cl:16][C:17]1[C:21]([Cl:22])=[C:20]([CH3:23])[NH:19][C:18]=1[C:24]([NH:26][CH:27]1[CH2:32][CH2:31][N:30]([C:2]2[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[C:4]([S:12][CH2:13][CH3:14])[N:3]=2)[CH2:29][CH2:28]1)=[O:25]

Participants

3

Reactant 2

HCID 68579996HCID 68579996, compound2×HCID 86038397Methyl 2-chloro-6-(ethylthio)pyrimidine-4-carboxylate2×

Product 1

HCID 68579937Methyl 2-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-6-(ethylthio)pyrimidine-4-carboxylate

Procedure

The title compound was synthesized by a method analogous to Example 9 by coupling methyl 2-chloro-6-(ethylthio)pyrimidine-4-carboxylate (Intermediate 96) with 3,4-dichloro-5-methyl-N-piperidin-4-yl-1H-pyrrole-2-carboxamide hydrochloride (Intermediate 1).

Sources & evidence

ORD record
ord-e126055884cc4e4aa79b2bb65be05da6
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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