HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 2,3-dihydro-7-methoxy-8-[5-(4-phenyl-1-piperazinyl)pentyloxy]cyclopenta[c][1]benzopyran-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 8-(5-bromopentyloxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927636 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | 2,3-dihydro-7-methoxy-8-[5-(4-phenyl-1-piperazinyl)pentyloxy]cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927694 | 97% |
Reaction Steps
Method B (10 h at 80° C.); starting materials: 8-(5-bromopentyloxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one (example 85) and 1-phenylpiperazine; yield 97%; fusion point 118°-120° C. (from isopropanol). Fumarate (x 0.5 C4H4O4): method E; yield 93%; fusion point 153°-155° C. (from isopropanol and TBME).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-a18af3b2d2b641faa36d78b3a98b6f22 |
| Source note | uspto-grants-1995_06 |