反应详情

Method B (10 h at 80° C.); starting materials: 8-(5-bromopentyloxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one (example 85) and 1-phenylpiperazine; yield 97%; fusion point 118°-120° C. (from isopropanol). Fumarate (x 0.5 C4H4O4): method E; yield 93%; fusion point 153°-155° C. (from isopropanol and TBME).

1. customMethod B (10 h at 80° C.)