3-Bromoisoxazole-5-carboxylic acid → HCID 68582525, compound

HRID 2234001Notes

Reaction equation

HRID 2234001 reaction equation
Cl.[Cl:2][C:3]1[C:7]([Cl:8])=[C:6]([CH3:9])[NH:5][C:4]=1[C:10]([NH:12][CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)=[O:11].Br[C:20]1[CH:24]=[C:23]([C:25]([OH:27])=[O:26])[O:22][N:21]=1>>[Cl:2][C:3]1[C:7]([Cl:8])=[C:6]([CH3:9])[NH:5][C:4]=1[C:10]([NH:12][CH:13]1[CH2:18][CH2:17][N:16]([C:20]2[CH:24]=[C:23]([C:25]([OH:27])=[O:26])[O:22][N:21]=2)[CH2:15][CH2:14]1)=[O:11]

Participants

3

Reactant 2

HCID 3277163-Bromoisoxazole-5-carboxylic acid2×HCID 68579996HCID 68579996, compound2×

Product 1

HCID 68582525HCID 68582525, compoundYield 33.6%

Procedure

The title compound was prepared via the procedure described in Example 1 from 182 mg (0.5 mmol) of 3,4-dichloro-5-methyl-N-piperidin-4-yl-1H-pyrrole-2-carboxamide hydrochloride (Intermediate 1) and 103 mg (0.54 mmol) of 3-bromoisoxazole-5-carboxylic acid (Intermediate 120), to afford the title compound as a white solid, (65 mg).

Workup

  1. customThe title compound was prepared via the procedure

Sources & evidence

ORD record
ord-c69f57e06ff64c1ea2980921d7ec3433
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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