O-Methylhydroxylamine hydrochloride → HCID 57397810, compound

HRID 2234003Notes

Reaction equation

HRID 2234003 reaction equation
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[S:19][C:20]([C:23]([OH:25])=O)=[CH:21][N:22]=2)[CH2:14][CH2:13]1)=[O:10].Cl.[O:27]([NH2:29])[CH3:28]>>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:13][CH2:14][N:15]([C:18]2[S:19][C:20]([C:23]([NH:29][O:27][CH3:28])=[O:25])=[CH:21][N:22]=2)[CH2:16][CH2:17]1)=[O:10]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 11463807HCID 11463807, compound

Product 1

HCID 57397810HCID 57397810, compound

Procedure

2-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-1,3-thiazole-5-carboxylic acid (Example 227, 100 mg, 0.25 mmol) was reacted with methoxylamine hydrochloride according to procedure described in Example 8 to afford the title compound (30 mg).

Sources & evidence

ORD record
ord-53c97134004b46d1b793cb44af523234
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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