Acetic Anhydride → HCID 68582826, compound

HRID 2234008Notes

Reaction equation

[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[S:19][C:20]([C:25]([OH:27])=[O:26])=[C:21]([CH2:23][OH:24])[N:22]=2)[CH2:14][CH2:13]1)=[O:10].[C:28](OC(=O)C)(=[O:30])[CH3:29]>N1C=CC=CC=1>[C:28]([O:24][CH2:23][C:21]1[N:22]=[C:18]([N:15]2[CH2:16][CH2:17][CH:12]([NH:11][C:9]([C:3]3[NH:4][C:5]([CH3:8])=[C:6]([Cl:7])[C:2]=3[Cl:1])=[O:10])[CH2:13][CH2:14]2)[S:19][C:20]=1[C:25]([OH:27])=[O:26])(=[O:30])[CH3:29]

Participants

Conditions

Temperature: 0 °C

Procedure

2-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-4-(hydroxymethyl)-1,3-thiazole-5-carboxylic acid (Example 237; 100 mg, 0.23 mmol) was dissolved in pyridine (2 ml) and cooled to 0° C. Acetic anhydride (21.8 μl, 0.230 mmol) was added and mixture was stirred at room temperature for 1 h. The mixture was diluted with

Workup

additionThe mixture was diluted with

Sources & evidence

ORD record: ord-dbb2498194064df1a7dd2c78d397bb22
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07709503B2

Reaction notes

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