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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2234008Generated: October 30, 2026

Acetic Anhydride → HCID 68582826, compound

https://huagongshe.com/reaction/2234008

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AnhydrideHCID 7918—
Reactant2-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-4-(hydroxymethyl)-1,3-thiazole-5-carboxylic acidHCID 68579777—
SolventPyridineHCID 1049—
ProductHCID 68582826HCID 68582826—

Reaction Conditions

Temperature0 °C

Reaction Steps

2-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-4-(hydroxymethyl)-1,3-thiazole-5-carboxylic acid (Example 237; 100 mg, 0.23 mmol) was dissolved in pyridine (2 ml) and cooled to 0° C. Acetic anhydride (21.8 μl, 0.230 mmol) was added and mixture was stirred at room temperature for 1 h. The mixture was diluted with

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07709503B2
Source datasetuspto-grants-2010_05
ORD IDord-dbb2498194064df1a7dd2c78d397bb22
Source noteuspto-grants-2010_05