Ammonia dioxane → N-{1-[5-(Aminosulfonyl)-1,3-thiazol-2-yl]piperidin-4-yl}-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide

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Reaction Steps

0.5 M ammonia/dioxane (10 ml, 5 mmol) was added to 2-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-1,3-thiazole-5-sulfonic acid (Example 254; 100 mg, 0.226 mmol) in a pressure bottle. The mixture was stirred at room temperature for 4 h. Excess solvent was removed in vacuo and the brown solid was dried in vacuo to give the title compound (56 mg).

Provenance & Evidence