Methyl 4-(4-aminopiperidin-1-yl)quinoline-2-carboxylate hydrochloride → Methyl 4-(4-{[(3,4-dichloro-5-cyano-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)quinoline-2-carboxylate

HRID 2234031Notes

Reaction equation

HRID 2234031 reaction equation
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([C:8]#[N:9])[NH:4][C:3]=1[C:10](Cl)=[O:11].Cl.[NH2:14][CH:15]1[CH2:20][CH2:19][N:18]([C:21]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:24]=[C:23]([C:31]([O:33][CH3:34])=[O:32])[CH:22]=2)[CH2:17][CH2:16]1>>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([C:8]#[N:9])[NH:4][C:3]=1[C:10]([NH:14][CH:15]1[CH2:20][CH2:19][N:18]([C:21]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:24]=[C:23]([C:31]([O:33][CH3:34])=[O:32])[CH:22]=2)[CH2:17][CH2:16]1)=[O:11]

Participants

3

Reactant 2

HCID 68580165Methyl 4-(4-aminopiperidin-1-yl)quinoline-2-carboxylate hydrochloride2×HCID 860383333,4-Dichloro-5-cyano-1H-pyrrole-2-carbonyl chloride2×

Product 1

HCID 68579768Methyl 4-(4-{[(3,4-dichloro-5-cyano-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)quinoline-2-carboxylate

Procedure

The title compound was prepared by an analogous procedure to Example 271 starting from 3,4-dichloro-5-cyano-1H-pyrrole-2-carbonyl chloride (Intermediate 132) and methyl 4-(4-aminopiperidin-1-yl)quinoline-2-carboxylate hydrochloride (Intermediate 136).

Sources & evidence

ORD record
ord-02601dca6daa456eb2c539a53c9e9ecd
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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