Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2234031Generated: November 1, 2026

Methyl 4-(4-aminopiperidin-1-yl)quinoline-2-carboxylate hydrochloride → Methyl 4-(4-{[(3,4-dichloro-5-cyano-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)quinoline-2-carboxylate

https://huagongshe.com/reaction/2234031

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-(4-aminopiperidin-1-yl)quinoline-2-carboxylate hydrochlorideHCID 68580165—
Reactant3,4-Dichloro-5-cyano-1H-pyrrole-2-carbonyl chlorideHCID 86038333—
ProductMethyl 4-(4-{[(3,4-dichloro-5-cyano-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)quinoline-2-carboxylateHCID 68579768—

Reaction Steps

The title compound was prepared by an analogous procedure to Example 271 starting from 3,4-dichloro-5-cyano-1H-pyrrole-2-carbonyl chloride (Intermediate 132) and methyl 4-(4-aminopiperidin-1-yl)quinoline-2-carboxylate hydrochloride (Intermediate 136).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07709503B2
Source datasetuspto-grants-2010_05
ORD IDord-02601dca6daa456eb2c539a53c9e9ecd
Source noteuspto-grants-2010_05