O-Methylhydroxylamine hydrochloride → HCID 86608341, compound

HRID 2234033Notes

Reaction equation

HRID 2234033 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]([OH:14])=O)[CH:8]=[C:7]2[N:15]1[CH2:20][CH2:19][CH:18]([NH:21][C:22]([C:24]2[NH:25][C:26]([CH3:31])=[C:27]([Cl:30])[C:28]=2[Cl:29])=[O:23])[CH2:17][CH2:16]1.Cl.[CH3:33][O:34][NH2:35]>>[CH3:33][O:34][NH:35][C:12]([C:9]1[CH:8]=[C:7]([N:15]2[CH2:16][CH2:17][CH:18]([NH:21][C:22]([C:24]3[NH:25][C:26]([CH3:31])=[C:27]([Cl:30])[C:28]=3[Cl:29])=[O:23])[CH2:19][CH2:20]2)[C:6]2[C:11](=[C:2]([F:1])[CH:3]=[CH:4][CH:5]=2)[N:10]=1)=[O:14]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 68580044HCID 68580044, compound

Product 1

HCID 86608341HCID 86608341, compound

Procedure

The title compound was prepared from 8-fluoro-4-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)quinoline-2-carboxylic acid (Example 280) and O-methylhydroxylamine hydrochloride via the procedure described for Example 8.

Sources & evidence

ORD record
ord-83b1b572a05249328fe92a922381b525
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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