O-Methylhydroxylamine hydrochloride → HCID 86608325, compound

HRID 2234045Notes

Reaction equation

HRID 2234045 reaction equation
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[N:23]=[C:22]([O:24][CH2:25][CH:26]3[CH2:30][O:29][C:28]([CH3:32])([CH3:31])[O:27]3)[N:21]=[C:20]([C:33](O)=[O:34])[CH:19]=2)[CH2:14][CH2:13]1)=[O:10].Cl.[O:37]([NH2:39])[CH3:38]>>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[N:23]=[C:22]([O:24][CH2:25][CH:26]3[CH2:30][O:29][C:28]([CH3:32])([CH3:31])[O:27]3)[N:21]=[C:20]([C:33]([NH:39][O:37][CH3:38])=[O:34])[CH:19]=2)[CH2:14][CH2:13]1)=[O:10]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 68579903HCID 68579903, compound

Product 1

HCID 86608325HCID 86608325, compound

Procedure

The title compound was synthesized by an analogous method to Example 8 starting from 6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]pyrimidine-4-carboxylic acid (Example 314) and methoxylamine hydrochloride.

Sources & evidence

ORD record
ord-4e004f0cdd144d36ac547825f69f4b98
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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