2-(4-Aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride → HCID 86608329, compound

HRID 2234047Notes

Reaction equation

HRID 2234047 reaction equation
Cl.NC1CCN(C2C=C(C=C(Cl)N=2)C(N)=O)CC1.[Cl:19][C:20]1[C:24]([Cl:25])=[C:23]([CH3:26])[NH:22][C:21]=1[C:27]([NH:29][CH:30]1[CH2:35][CH2:34][N:33]([C:36]2[CH:41]=[C:40]([C:42]([NH:44][O:45][CH3:46])=[O:43])[N:39]=[C:38]([O:47][CH2:48][CH2:49][NH:50]C(=O)OC(C)(C)C)[N:37]=2)[CH2:32][CH2:31]1)=[O:28]>>[NH2:50][CH2:49][CH2:48][O:47][C:38]1[N:39]=[C:40]([C:42]([NH:44][O:45][CH3:46])=[O:43])[CH:41]=[C:36]([N:33]2[CH2:34][CH2:35][CH:30]([NH:29][C:27]([C:21]3[NH:22][C:23]([CH3:26])=[C:24]([Cl:25])[C:20]=3[Cl:19])=[O:28])[CH2:31][CH2:32]2)[N:37]=1

Participants

3

Reactant 2

HCID 866082552-(4-Aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochlorideHCID 86608344HCID 86608344, compound

Product 1

HCID 86608329HCID 86608329, compound

Procedure

The title compound was synthesized by a method analogous to Intermediate 70 starting from tert-butyl 2-({4-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-6-[(methoxyamino)carbonyl]pyrimidin-2-yl}oxy)ethylcarbamate (Example 322).

Sources & evidence

ORD record
ord-5e0bb856b56f465d9769aecf1440a12a
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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