2-Bromo-1,3-thiazole-4-carbonitrile → HCID 68579886, compound

HRID 2234056Notes

Reaction equation

HRID 2234056 reaction equation
Cl.[Cl:2][C:3]1[C:7]([Cl:8])=[C:6]([CH3:9])[NH:5][C:4]=1[C:10]([NH:12][CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)=[O:11].Br[C:20]1[S:21][CH:22]=[C:23]([C:25]#[N:26])[N:24]=1>>[Cl:2][C:3]1[C:7]([Cl:8])=[C:6]([CH3:9])[NH:5][C:4]=1[C:10]([NH:12][CH:13]1[CH2:18][CH2:17][N:16]([C:20]2[S:21][CH:22]=[C:23]([C:25]#[N:26])[N:24]=2)[CH2:15][CH2:14]1)=[O:11]

Participants

3

Reactant 2

HCID 454804392-Bromo-1,3-thiazole-4-carbonitrileHCID 68579996HCID 68579996, compound2×

Product 1

HCID 68579886HCID 68579886, compound

Procedure

The title compound was prepared as described for Example 321 from 3,4-dichloro-5-methyl-N-piperidin-4-yl-1H-pyrrole-2-carboxamide hydrochloride (Intermediate 1) and 2-bromo-1,3-thiazole-4-carbonitrile (prepared as described in J. Am. Chem. Soc. 1952, 74, 5799).

Sources & evidence

ORD record
ord-78e6720e4bd9498782c3005963b49dce
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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