2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-3-vinyl-1H-indole methanol → 3-Ethyl-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-1H-indole

HRID 2234078Notes

Reaction equation

HRID 2234078 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[N:5][C:6]([C:22]2[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=2)=[CH:7][C:8]=1[C:9]1(CO)[CH:17]([CH:18]=[CH2:19])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10]1>[Pd]>[CH2:18]([C:17]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][C:9]=1[C:8]1[CH:7]=[C:6]([C:22]2[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=2)[N:5]=[N:4][C:3]=1[O:2][CH3:1])[CH3:19]

Participants

3

Reactant 1

HCID 866120502-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-3-vinyl-1H-indole methanol

Product 1

HCID 230924553-Ethyl-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-1H-indole

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

12 mg Palladium, 10% on charcole are added to a solution of 70 mg 2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-3-vinyl-1H-indole methanol and the reaction mixture stirred under an hydrogen atmosphere for 4 hours. The catalyst is removed by filtration and the solvens by evaporation yielding the product which was used without further purification

Workup

  1. customThe catalyst is removed by filtration
  2. customthe solvens by evaporation
  3. customyielding the product which
  4. customwas used without further purification

Sources & evidence

ORD record
ord-e563169108b34dc588c7ee27e0ed70cc
Source dataset
uspto-grants-2010_05
Patent number
US07709466B2

Reaction notes

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