Triethylamine → HCID 20522397, compound

HRID 223408Notes

Reaction equation

HRID 223408 reaction equation
[C:1](Cl)(=[O:6])[CH2:2][CH2:3][CH2:4][CH3:5].[NH:8]([C:10]1[C:11](=[O:22])[N:12]([CH3:21])[C:13]2[C:18]([N:19]=1)=[CH:17][C:16]([Cl:20])=[CH:15][CH:14]=2)[NH2:9].C(N(CC)CC)C>O1CCOCC1>[CH3:21][N:12]1[C:13]2[C:18](=[CH:17][C:16]([Cl:20])=[CH:15][CH:14]=2)[N:19]=[C:10]([NH:8][NH:9][C:1](=[O:6])[CH2:2][CH2:3][CH2:4][CH3:5])[C:11]1=[O:22]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 61186Valeryl chlorideHCID 13487177HCID 13487177, compound

Product 1

HCID 20522397HCID 20522397, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Pentanoyl chloride (52.6 mmol) is added dropwise to a solution of 3-hydrazino-1-methyl-6-chloro-1H-quinoxalin-2-one (43.8 mmol) and triethylamine (52.6 mmol) in 500 ml. of dioxane and stirred at room temperature for 2 hours. The dioxane is removed under vacuum and the residue washed with water and ether, filtered and dried under high vacuum at 65° for 3 hours to give crude product.

Workup

  1. customThe dioxane is removed under vacuum
  2. washthe residue washed with water and ether
  3. filtrationfiltered
  4. customdried under high vacuum at 65° for 3 hours
  5. customto give crude product

Sources & evidence

ORD record
ord-f7034a5b544f4853895e8be93fd3efb0
Source dataset
uspto-grants-1982_10
Patent number
US04354027

Reaction notes

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