反应详情

12.25 g 1-(6-Chloro-3-methoxy-pyridazin-4-yl)-propan-1-ol is dissolved in 410 ml tetrahydrofuran and 105 g of manganese dioxide is added. The reaction is stirred for 24 h at RT. Solids are removed by filtration, and the solution is treated with a further 105 g of manganese dioxide for 16 h at RT. Solids are removed by filtration, and the solvent is removed under reduced pressure. The product is purified by silica gel chromatography, eluting with a gradient of ethyl acetate in heptane. Yield 3.25 g. LC-MS (ES+) 201 (M+H)+.

1. customSolids are removed by filtration
2. additionthe solution is treated with a further 105 g of manganese dioxide for 16 h at RT
3. customSolids are removed by filtration
4. customthe solvent is removed under reduced pressure
5. customThe product is purified by silica gel chromatography
6. washeluting with a gradient of ethyl acetate in heptane