Triethylamine → HCID 20522409, compound

HRID 223410Notes

Reaction equation

HRID 223410 reaction equation
[NH:1]([C:3]1[C:4](=[O:18])[N:5]([CH3:17])[C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([C:13]([F:16])([F:15])[F:14])=[CH:8][CH:7]=2)[NH2:2].C(N(CC)CC)C.[CH3:26][CH:27]([CH3:32])[CH2:28][C:29](Cl)=[O:30]>O1CCOCC1>[CH3:17][N:5]1[C:6]2[C:11](=[CH:10][C:9]([C:13]([F:16])([F:15])[F:14])=[CH:8][CH:7]=2)[N:12]=[C:3]([NH:1][NH:2][C:29](=[O:30])[CH2:28][CH:27]([CH3:32])[CH3:26])[C:4]1=[O:18]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 66054Isovaleryl chlorideHCID 13487178HCID 13487178, compound

Product 1

HCID 20522409HCID 20522409, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 3-hydrazino-1-methyl-6-trifluoromethyl-1H-quinoxalin-2-one (10.0 g., 52.6 mmol) and triethylamine (6.38 g., 63.2 mmol) in 500 ml. of dioxane is added dropwise 3-methylbutanoyl chloride (7.62 g., 65.2 mmol) and the mixture stirred at room temperature for 20 hours. The dioxane is then removed under vacuum and the residue washed with water and ether, filtered and dried under vacuum to give the product.

Workup

  1. customThe dioxane is then removed under vacuum
  2. washthe residue washed with water and ether
  3. filtrationfiltered
  4. customdried under vacuum
  5. customto give the product

Sources & evidence

ORD record
ord-b8c69f22a9b14a619e018e317d01bb1b
Source dataset
uspto-grants-1982_10
Patent number
US04354027

Reaction notes

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