HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 68638865, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 67148781 | HCID 67148781 | — |
| Catalyst | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 68638865 | HCID 68638865 | 101% |
Reaction Steps
1.30 g 6-(Piperidin-1-ylmethyl)-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester (see example 37) are dissolved in 2 mL dichloromethane. 0.97 mL trifluoroacetic acid and 4 drops of water are added. The reaction mixture is stirred overnight at rt. Concentration in vacuo affords 1.05 g (100%) crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709466B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-8567664b8bf746ffac6f1998e6b5a724 |
| Source note | uspto-grants-2010_05 |