Trifluoroacetic acid → HCID 68638865, compound

HRID 2234106Notes

Reaction equation

HRID 2234106 reaction equation
C(OC([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH2:17][N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[CH:15]=2)[CH:10]=[C:9]1[C:24]1[CH:29]=[C:28]([C:30]2[CH:35]=[CH:34][N:33]=[CH:32][CH:31]=2)[N:27]=[N:26][C:25]=1[O:36][CH3:37])=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl.O>[CH3:37][O:36][C:25]1[N:26]=[N:27][C:28]([C:30]2[CH:31]=[CH:32][N:33]=[CH:34][CH:35]=2)=[CH:29][C:24]=1[C:9]1[NH:8][C:16]2[C:11]([CH:10]=1)=[CH:12][CH:13]=[C:14]([CH2:17][N:18]1[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1)[CH:15]=2

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67148781HCID 67148781, compound

Product 1

HCID 68638865HCID 68638865, compoundYield 101%

Reagents, catalysts & solvents 2

HCID 962WaterCatalystHCID 6344DichloromethaneSolvent

Procedure

1.30 g 6-(Piperidin-1-ylmethyl)-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester (see example 37) are dissolved in 2 mL dichloromethane. 0.97 mL trifluoroacetic acid and 4 drops of water are added. The reaction mixture is stirred overnight at rt. Concentration in vacuo affords 1.05 g (100%) crude product.

Workup

  1. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-8567664b8bf746ffac6f1998e6b5a724
Source dataset
uspto-grants-2010_05
Patent number
US07709466B2

Reaction notes

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