N-bromobutanimide → HCID 135961905, compound

HRID 2234126Notes

Reaction equation

HRID 2234126 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]1[C:11](=[O:21])[NH:12][N:13]=[C:14]([C:16]2[CH:17]=[N:18][NH:19][CH:20]=2)[CH:15]=1.[Br:22]N1C(=O)CCC1=O>C(COC)OC>[Br:22][C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]=1[C:10]1[C:11](=[O:21])[NH:12][N:13]=[C:14]([C:16]2[CH:20]=[N:19][NH:18][CH:17]=2)[CH:15]=1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 135961844HCID 135961844, compound

Product 1

HCID 135961905HCID 135961905, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

39 mg of 4-(1H-indol-2-yl)-6-(1H-pyrazol-4-yl)-2H-pyridazin-3-one is dissolved in dimethoxyethane and 28 mg of N-bromosuccinimide is added. The solution is stirred for 3 h at RT. The product is purified by preparative RP-HPLC eluting with a gradient of 0-100% acetonitrile in water (+0.01% trifluoroacetic acid). Yield 11 mg. LC-MS (ES+) 355/357 (M+H)+.

Workup

  1. customThe product is purified by preparative RP-HPLC
  2. washeluting with a gradient of 0-100% acetonitrile in water (+0.01% trifluoroacetic acid)

Sources & evidence

ORD record
ord-404f4f3664c2416bb8163748d1a92c6c
Source dataset
uspto-grants-2010_05
Patent number
US07709466B2

Reaction notes

Loading…