1-Methylpiperazine → HCID 68637838, compound

HRID 2234130Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:17](=O)[CH3:18])[CH:15]=2)[CH:10]=[C:9]1[C:20]1[CH:25]=[C:24]([C:26]2[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=2)[N:23]=[N:22][C:21]=1[O:32][CH3:33])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:34][N:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1>>[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH:17]([N:38]3[CH2:39][CH2:40][N:35]([CH3:34])[CH2:36][CH2:37]3)[CH3:18])[CH:15]=2)[CH:10]=[C:9]1[C:20]1[CH:25]=[C:24]([C:26]2[CH:27]=[CH:28][N:29]=[CH:30][CH:31]=2)[N:23]=[N:22][C:21]=1[O:32][CH3:33])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 68637014HCID 68637014, compound

Product 1

HCID 68637838HCID 68637838, compound

Conditions

Temperature: 65 °C

Procedure

180 mg resin bound (2.57 mmol/g) sodium cyano borhydride are added to a solution of 80 mg 6-acetyl-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester, 22 mg N-methyl-piperazine and 0.062 ml acidic acid and the mixture stirred over night at 65° C. The crude product is isolated by filtration and evaporation of the solvent and is used without further purification.

Sources & evidence

ORD record: ord-01bf168b540a480c8d926cd03f38de5f
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07709466B2

Reaction notes

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