Hydrochloric Acid → HCID 136367323, compound

HRID 2234134Notes

Reaction equation

HRID 2234134 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]([C:15]1[CH:20]=[C:19]([C:21]3[CH:26]=[C:25]([CH3:27])[C:24]([OH:28])=[C:23]([CH3:29])[CH:22]=3)[N:18]=[N:17][C:16]=1[O:30][CH3:31])=[CH:9]2)=[O:5])C.[OH-].[Na+].Cl>C(O)C>[OH:28][C:24]1[C:25]([CH3:27])=[CH:26][C:21]([C:19]2[N:18]=[N:17][C:16]([O:30][CH3:31])=[C:15]([C:10]3[NH:11][C:12]4[C:8]([CH:9]=3)=[CH:7][C:6]([C:4]([OH:5])=[O:3])=[CH:14][CH:13]=4)[CH:20]=2)=[CH:22][C:23]=1[CH3:29]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 136367324HCID 136367324, compound

Product 1

HCID 136367323HCID 136367323, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

480 mg of 2-[6-(4-hydroxy-3,5-dimethyl-phenyl)-3-methoxy-pyridazin-4-yl]-1H-indole-5-carboxylic acid ethyl ester is dissolved in 4 ml ethanol and 4 ml aqueous 2N NaOH and heated by microwave irradiation for 10 min at 150° C. The solution is neutralized with aqueous HCl and the product is purified by preparative RP-HPLC eluting with a gradient of 0-100% acetonitrile in water (+0.01% trifluoroacetic acid).

Workup

  1. customthe product is purified by preparative RP-HPLC
  2. washeluting with a gradient of 0-100% acetonitrile in water (+0.01% trifluoroacetic acid)

Sources & evidence

ORD record
ord-70c86af6667e48e3929843da47d7c498
Source dataset
uspto-grants-2010_05
Patent number
US07709466B2

Reaction notes

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