反应详情

温度

0 °C

N-(2,2-Diethoxyethyl)-3-phenethyloxy-N-phenyl-propanamide (Example 6a), 0.11 g) was dissolved in anhydrous dioxane (5 mL) and cooled to 0° C. Concentrated hydrochloric acid (0.3 mL) was added dropwise to the stirred solution at 0° C. The resultant reaction mixture was stirred at 0° C. for 2 hours. The reaction mixture was then poured into dichloromethane (10 mL) and washed with water (2×10 mL) and brine (10 mL). The organic layer was isolated, dried over anhydrous magnesium sulphate, filtered and concentrated to give the sub-titled compound (0.07 g) as a viscous oil.

1. customThe resultant reaction mixture
2. washwashed with water (2×10 mL) and brine (10 mL)
3. customThe organic layer was isolated
4. dry with materialdried over anhydrous magnesium sulphate
5. filtrationfiltered
6. concentrationconcentrated