反应详情

温度

100 °C

Ground KOH (1.2 g) is added to a solution of (R)-N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine (3.1 g) in DMSO (10 ml), bubbled with a moderate stream of nitrogen, and the mixture is stirred and heated at 100° C. for 1 hour. After cooling down to lab temperature, the mixture is diluted with water (30 ml) and the racemic product is extracted with toluene. After evaporation, 2.6 g (84%) of (RS)-N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine is obtained.

1. custombubbled with a moderate stream of nitrogen
2. temperatureAfter cooling down to lab temperature
3. additionthe mixture is diluted with water (30 ml)
4. extractionthe racemic product is extracted with toluene
5. customAfter evaporation