Potassium Hydroxide → N,N-Dimethyl-3-((naphthalen-1-yl)oxy)-3-(thiophen-2-yl)propan-1-amine

Participants

Reaction Conditions

Reaction Steps

Ground KOH (1.2 g) is added to a solution of (R)-N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine (3.1 g) in DMSO (10 ml), bubbled with a moderate stream of nitrogen, and the mixture is stirred and heated at 100° C. for 1 hour. After cooling down to lab temperature, the mixture is diluted with water (30 ml) and the racemic product is extracted with toluene. After evaporation, 2.6 g (84%) of (RS)-N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine is obtained.

Provenance & Evidence