HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine D-tartrate → (S)-N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine D-tartrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine D-tartrate | HCID 86625060 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (S)-N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine D-tartrate | HCID 86625059 | — |
Reaction Steps
(RS)-N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine-D-tartrate (461 g) is dissolved in tetrahydrofuran (900 ml) while hot. After cooling down to lab temperature, the mixture is stirred for 24 hours. The precipitated crystals are re-crystallized from tetrahydrofuran (400 ml) once more using the same procedure. The yield is 117 g (25%). Optical purity is 99% ee (CE).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709662B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-da3b1a9d355d424fb640704e86298b29 |
| Source note | uspto-grants-2010_05 |