HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine D-tartrate → (S)-N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine D-tartrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine D-tartrate | HCID 86625060 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (S)-N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine D-tartrate | HCID 86625059 | — |
Reaction Steps
(RS)-N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine-D-tartrate (461 g) is dissolved in ethanol (700 ml) under reflux. After gradual cooling to lab temperature, the mixture is stirred for 164 hours. The precipitated crystals are sucked off and washed with ethanol. The yield is 150 g (32%). Optical purity is 98% ee (CE).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709662B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-a18cbddc99634ebcb954c8e170fc8326 |
| Source note | uspto-grants-2010_05 |