HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl methyl ether → 2,3-dihydro-7-methoxy-8-[4-(4-phenyl-1-piperidinyl)butyloxy]cyclopenta[c][1]benzopyran-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 2,3-dihydro-8-[4-(methanesulfonyloxy)butyloxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one | HCID 19927634 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2,3-dihydro-7-methoxy-8-[4-(4-phenyl-1-piperidinyl)butyloxy]cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927653 | 73% |
Reaction Steps
Method B (16 h at 60° C.); starting materials: 2,3-dihydro-8-[4-(methanesulfonyloxy)butyloxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one (example 84) and 4-phenylpiperidine; yield 73%; fusion point 104°-105° C. (from TBME). Fumarate: method E; yield 77%; fusion point 192°-193° C. (from isopropanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-dba2c9063871462d98200d17d9e933af |
| Source note | uspto-grants-1995_06 |