Trifluoroacetic acid → HCID 68684791, compound

HRID 2234346Notes

Reaction equation

HRID 2234346 reaction equation
[CH:1]1([N:6]2[CH2:16][CH2:15][C:14](=[O:17])[N:13]([CH3:18])[C:12]3[C:7]2=[N:8][C:9]([NH:19][C:20]2[CH:42]=[CH:41][C:23]([C:24]([NH:26][CH:27]4[CH2:33][CH2:32][CH2:31][CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28]4)=[O:25])=[CH:22][C:21]=2[O:43][CH3:44])=[N:10][CH:11]=3)[CH2:5][CH2:4][CH2:3][CH2:2]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH:29]1[CH2:30][CH2:31][CH2:32][CH2:33][CH:27]([NH:26][C:24](=[O:25])[C:23]2[CH:41]=[CH:42][C:20]([NH:19][C:9]3[N:8]=[C:7]4[C:12]([N:13]([CH3:18])[C:14](=[O:17])[CH2:15][CH2:16][N:6]4[CH:1]4[CH2:5][CH2:4][CH2:3][CH2:2]4)=[CH:11][N:10]=3)=[C:21]([O:43][CH3:44])[CH:22]=2)[CH2:28]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68685387HCID 68685387, compound

Product 1

HCID 68684791HCID 68684791, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl 3-[[4-[(2-cyclopentyl-6-methyl-5-oxo-2,6,9,11-tetrazabicyclo[5.4.0]undeca-7,9,11-trien-10-yl)amino]-3-methoxy-benzoyl]amino]azepane-1-carboxylate (Example 348; 149 mg, 0.25 mmol) in DCM (2 mL) was treated with TFA (1 mL) The resulting solution was stirred at ambient temperature for 5 hours.

Sources & evidence

ORD record
ord-477c1472ff954f6ea39f3c5960227f2a
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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