HCID 43234129, compound → 1-Cyclopropylpiperidin-4-amine

HRID 2234355Notes

Reaction equation

HRID 2234355 reaction equation
C([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([CH:15]2[CH2:17][CH2:16]2)[CH2:11][CH2:10]1)C1C=CC=CC=1>[Pd].CO>[CH:15]1([N:12]2[CH2:13][CH2:14][CH:9]([NH2:8])[CH2:10][CH2:11]2)[CH2:17][CH2:16]1

Participants

4

Reactant 1

HCID 43234129HCID 43234129, compound2×

Product 1

HCID 162276441-Cyclopropylpiperidin-4-amine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
30 °C

Procedure

N-benzyl-1-cyclopropyl-piperidin-4-amine (Intermediate 25; 2.3 g 10 mmol), 10% Palladium on Carbon (230 mg) and Methanol (230 mL) were combined and heated with stirring at 30° C. under Hydrogen at 5 bar pressure for 16 hours.

Workup

  1. temperatureheated

Sources & evidence

ORD record
ord-a08177c815a7467f98aa55f3f6bbf70f
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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