HRID223437

反应详情

EQUATION

反应方程式

HRID 223437 的结构方程式

AUXILIARIES

试剂、催化剂与溶剂

1

PROCEDURE

实验过程

A 0.08 m. quantity each of 2-amino-5,5-dimethyl-7-keto-4,5,6,7-tetrahydrobenzothiazole and α-bromoacetophenone are mixed in 150 ml. of chloroform and heated at reflux for 4 hours. The slurry is filtered hot and the insoluble intermediate product is suspended in 600 ml. of water containing 25 g. of sodium acetate. This suspension is heated slowly to boil over 21/2 hours, then allowed to cool. The product is filtered off, washed well with water and dried yielding 12.5 g. of product melting at 175°-178° C. and having the structure: ##STR9##

WORKUP

后处理

  1. temperatureat reflux for 4 hours
  2. filtrationThe slurry is filtered hot
  3. temperatureThis suspension is heated slowly
  4. custom2 hours
  5. temperatureto cool
  6. filtrationThe product is filtered off
  7. washwashed well with water
  8. customdried
  9. customyielding 12.5 g