Isopropyl iodide → Methyl 4-amino-3-isopropoxybenzoate

HRID 2234383노트

반응식

HRID 2234383 반응식
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[C:6]([OH:11])[CH:5]=1.C(=O)([O-])[O-].[Cs+].[Cs+].I[CH:20]([CH3:22])[CH3:21]>CC(C)=O>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[C:6]([O:11][CH:20]([CH3:22])[CH3:21])[CH:5]=1

참가 물질

5

반응물 3

HCID 6362Isopropyl iodide2회HCID 10796Cesium carbonateHCID 7020619Benzoic acid, 4-amino-3-hydroxy-, methyl ester

생성물 1

HCID 43380211Methyl 4-amino-3-isopropoxybenzoate

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
120 °C

실험 절차

Methyl3-hydroxy-4-aminobenzoate (ABCR: 100 mg, 0.60 mmol) & caesium carbonate (396 mg, 1.22 mmol) were taken up in acetone (4 mL) and 2-iodopropane (90 μl, 0.90 mmol) added and reaction heated in microwave (CEM discover; 150 W) to 120° C. and held for 30 mins A further aliquot of 2-iodopropane (90 μl, 0.90 mmol) was added and reaction heated again to 120° C. in microwave, holding for a further 30 mins

후처리

  1. customreaction
  2. customreaction
  3. temperatureheated again to 120° C. in microwave
  4. waitholding for a further 30 mins

출처 및 근거

ORD 기록
ord-c197392e13f24d46bd73a6660601618d
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709471B2

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