HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl iodide → Methyl 4-amino-3-isopropoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Benzoic acid, 4-amino-3-hydroxy-, methyl ester | HCID 7020619 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Methyl 4-amino-3-isopropoxybenzoate | HCID 43380211 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
Methyl3-hydroxy-4-aminobenzoate (ABCR: 100 mg, 0.60 mmol) & caesium carbonate (396 mg, 1.22 mmol) were taken up in acetone (4 mL) and 2-iodopropane (90 μl, 0.90 mmol) added and reaction heated in microwave (CEM discover; 150 W) to 120° C. and held for 30 mins A further aliquot of 2-iodopropane (90 μl, 0.90 mmol) was added and reaction heated again to 120° C. in microwave, holding for a further 30 mins
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709471B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-c197392e13f24d46bd73a6660601618d |
| Source note | uspto-grants-2010_05 |