Sodium hydride → HCID 86617554, compound

HRID 2234435Notes

Reaction equation

HRID 2234435 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]2[C:10](=[CH:11][N:12]=1)[N:9]([CH3:13])[C:8](=[O:14])[CH2:7][CH2:6][N:5]2[CH2:15][C:16]1C(C)=NOC=1C.Cl.ClC[CH2:26][N:27](C)[CH3:28].[H-].[Na+]>>[Cl:1][C:2]1[N:3]=[C:4]2[C:10]([N:9]([CH3:13])[C:8](=[O:14])[CH2:7][CH2:6][N:5]2[CH2:15][CH2:16][N:27]([CH3:28])[CH3:26])=[CH:11][N:12]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 11636816N,N-Dimethylaminoethyl chloride hydrochlorideHCID 86617551HCID 86617551, compound

Product 1

HCID 86617554HCID 86617554, compound

Procedure

The title compound was prepared by an analogous method to the preparation of Intermediate 156, on a 0.3 mmol scale, utilising 2 chloroethyldimethylamine hydrochloride (Aldrich; 52 mg, 0.36 mmol) and Sodium Hydride (60% mineral oil dispersion; 36 mg, 0.75 mmol), as a solid (84 mg, 98%).

Sources & evidence

ORD record
ord-e59dae28d5f047ca8bbe7b31eb4b5862
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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