Sodium hydride → HCID 86617556, compound

HRID 2234437Notes

Reaction equation

HRID 2234437 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]2[C:10](=[CH:11][N:12]=1)[N:9]([CH3:13])[C:8](=[O:14])[CH2:7][CH2:6][N:5]2[CH2:15][C:16]1C(C)=NOC=1C.Cl.ClCC[N:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1.[H-].[Na+]>>[Cl:1][C:2]1[N:3]=[C:4]2[C:10]([N:9]([CH3:13])[C:8](=[O:14])[CH2:7][CH2:6][N:5]2[CH2:15][CH2:16][N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)=[CH:11][N:12]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)HCID 86617551HCID 86617551, compound

Product 1

HCID 86617556HCID 86617556, compound

Procedure

The title compound was prepared by an analogous method to the preparation of Intermediate 156, on a 0.3 mmol scale, utilising N-(2-chloroethyl)morpholine hydrochloride (Aldrich; 67 mg, 0.36 mmol) and Sodium Hydride (60% mineral oil dispersion; 36 mg, 0.75 mmol), as a solid (95 mg, 97%).

Sources & evidence

ORD record
ord-41706157ed9d49de81a0aa0aeb21b06e
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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