反应详情

5-ethoxy-2-fluoro-4-nitrobenzoic acid (Intermediate 172; 1.24 g, 5.40 mmol) was stirred and dissolved in ethanol:DMF (50 mL:5 mL) over 5% Pd/C (125 mg) and hydrogenated at ambient temperature for 4 hours. The catalyst was filtered and washed with ethanol and the solvent evaporated. The resultant material was purified on a silica column, eluting with 0-5% MeOH/DCM. Product containing fractions were combined and evaporated to yield the title compound as a pale brown solid (433 mg, 40%)

1. filtrationThe catalyst was filtered
2. washwashed with ethanol
3. customthe solvent evaporated
4. customThe resultant material was purified on a silica column
5. washeluting with 0-5% MeOH/DCM
6. additionProduct containing fractions
7. customevaporated