反应详情

The title compound was prepared by an analogous method to the preparation of Intermediate 173, on a 2.64 mol scale, utilising 4-amino-1-methylpiperidine (Fluorochem; 508 mg, 3.96 mmol) after purification on a silica column (gradient (3-4% ammonia in methanol/DCM), as a pale brown foam (647 mg, 82%).

1. customafter purification on a silica column (gradient (3-4% ammonia in methanol/DCM)