HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-1-methylpiperidine → 4-amino-5-chloro-N-(1-ethyl-4-piperidyl)-2-fluoro-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-1-methylpiperidine | HCID 2737531 | — |
| Reactant | 4-amino-5-chloro-2-fluoro-N-(1-methyl-4-piperidyl)benzamide | HCID 68682466 | — |
| Product | 4-amino-5-chloro-N-(1-ethyl-4-piperidyl)-2-fluoro-benzamide | HCID 68683071 | — |
Reaction Steps
The title compound was prepared by an analogous method to the preparation of Intermediate 173, on a 2.64 mol scale, utilising 4-amino-1-methylpiperidine (Fluorochem; 508 mg, 3.96 mmol) after purification on a silica column (gradient (3-4% ammonia in methanol/DCM), as a pale brown foam (647 mg, 82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709471B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-13b7523a44fb4c0195c13ae594d2edd6 |
| Source note | uspto-grants-2010_05 |