N,N-Dimethyl-1,4-cyclohexanediamine → 4-amino-5-chloro-N-(4-dimethylaminocyclohexyl)-2-fluoro-benzamide

HRID 2234449Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2234449
[NH2:1][C:2]1[C:17]([Cl:18])=[CH:16][C:5]([C:6]([NH:8][CH:9]2[CH2:14][CH2:13]N(C)[CH2:11][CH2:10]2)=[O:7])=[C:4]([F:19])[CH:3]=1.NC1CC[CH:24]([N:27]([CH3:29])[CH3:28])CC1>>[NH2:1][C:2]1[C:17]([Cl:18])=[CH:16][C:5]([C:6]([NH:8][CH:9]2[CH2:10][CH2:11][CH:24]([N:27]([CH3:29])[CH3:28])[CH2:13][CH2:14]2)=[O:7])=[C:4]([F:19])[CH:3]=1

Komponenten

3

Edukt 2

HCID 345823N,N-Dimethyl-1,4-cyclohexanediamineHCID 686824664-amino-5-chloro-2-fluoro-N-(1-methyl-4-piperidyl)benzamide

Produkt 1

HCID 686828744-amino-5-chloro-N-(4-dimethylaminocyclohexyl)-2-fluoro-benzamide

Versuchsvorschrift

The title compound was prepared by an analogous method to the preparation of Intermediate 173, on a 2.64 mol scale, utilising 1-amino-4-dimethylaminocyclohexane (ABChem. Inc.; 472 mg, 3.31 mmol) after purification on a silica column (gradient (3-4% ammonia in methanol/DCM), as a pale brown foam (716 mg, 86%).

Aufarbeitung

  1. customafter purification on a silica column (gradient (3-4% ammonia in methanol/DCM)

Quellen und Nachweise

ORD-Eintrag
ord-63e5b80475214b9d9cde5d5136bc27e2
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07709471B2

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