N,N-Dimethyl-1,4-cyclohexanediamine → 4-amino-5-chloro-N-(4-dimethylaminocyclohexyl)-2-fluoro-benzamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	N,N-Dimethyl-1,4-cyclohexanediamine	HCID 345823	—
Edukt	4-amino-5-chloro-2-fluoro-N-(1-methyl-4-piperidyl)benzamide	HCID 68682466	—
Produkt	4-amino-5-chloro-N-(4-dimethylaminocyclohexyl)-2-fluoro-benzamide	HCID 68682874	—

Reaktionsschritte

The title compound was prepared by an analogous method to the preparation of Intermediate 173, on a 2.64 mol scale, utilising 1-amino-4-dimethylaminocyclohexane (ABChem. Inc.; 472 mg, 3.31 mmol) after purification on a silica column (gradient (3-4% ammonia in methanol/DCM), as a pale brown foam (716 mg, 86%).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07709471B2
Quelldatensatz	uspto-grants-2010_05
ORD ID	ord-63e5b80475214b9d9cde5d5136bc27e2
Quellennotiz	uspto-grants-2010_05