(3R)-1-Methyl-3-PyrrolidinaMine hydrochloride → 4-amino-5-ethoxy-2-fluoro-N-[(3R)-1-methylpyrrolidin-3-yl]benzamide

HRID 2234456Notes

Reaction equation

HRID 2234456 reaction equation
[NH2:1][C:2]1[C:17]([O:18][CH2:19][CH3:20])=[CH:16][C:5]([C:6]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([CH3:15])[CH2:11]C2)=[O:7])=[C:4]([F:21])[CH:3]=1.Cl.Cl.CN1CC[C@@H](N)C1>>[NH2:1][C:2]1[C:17]([O:18][CH2:19][CH3:20])=[CH:16][C:5]([C:6]([NH:8][C@@H:9]2[CH2:14][CH2:13][N:12]([CH3:15])[CH2:11]2)=[O:7])=[C:4]([F:21])[CH:3]=1

Participants

3

Reactant 2

HCID 53256048(3R)-1-Methyl-3-PyrrolidinaMine hydrochloride2×HCID 68684038HCID 68684038, compound

Product 1

HCID 686836314-amino-5-ethoxy-2-fluoro-N-[(3R)-1-methylpyrrolidin-3-yl]benzamide

Procedure

The title compound was prepared by an analogous method to the preparation of Intermediate 169, on a 0.5 mmol scale, utilising (3R)-1-methylpyrrolidin-3-amine dihydrochloride (Intermediate 184; 129 mg, 0.75 mmol), as a white solid (95 mg, 68%).

Sources & evidence

ORD record
ord-4786d7962eaa4743991a7ef4cd931654
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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