HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3R)-1-Methyl-3-PyrrolidinaMine hydrochloride → 4-amino-5-ethoxy-2-fluoro-N-[(3R)-1-methylpyrrolidin-3-yl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3R)-1-Methyl-3-PyrrolidinaMine hydrochloride | HCID 53256048 | — |
| Reactant | HCID 68684038 | HCID 68684038 | — |
| Product | 4-amino-5-ethoxy-2-fluoro-N-[(3R)-1-methylpyrrolidin-3-yl]benzamide | HCID 68683631 | — |
Reaction Steps
The title compound was prepared by an analogous method to the preparation of Intermediate 169, on a 0.5 mmol scale, utilising (3R)-1-methylpyrrolidin-3-amine dihydrochloride (Intermediate 184; 129 mg, 0.75 mmol), as a white solid (95 mg, 68%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709471B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-4786d7962eaa4743991a7ef4cd931654 |
| Source note | uspto-grants-2010_05 |